We have built various optical imaging systems over broad temporal and spatial scales.
- The Fluorescence Lifetime Imaging Microscope (FLIM) (left) enables the ultra-fast registration of photons (~25 ps) at a high spatial resolution (~200nm). This home built system has an unique synchronized scanning system to allow two independent image acquisition and pumping.
- The single molecule microscope (middle) integrates multiple imaging modalities in a single system. An inverted objective (1.4 N.A.) allows the widefield, Total internal reflection (TIRF), and highly inclined Illumination (HILO) imaging of single molecules with a high temporal resolution. The upright objective enables the light sheet imaging mode, which is capable of obtaining a high-speed volumetric imaging of a live animal (such as zebrafish).
- A rencet developed miniscope (right), in collaboration with neuron scientists), aims to monitor the neural activities in freely-moving mouse/rat. The miniscope features centimeter size and extremely low weight (~3g) to allow the real-time imaging of Ca2+ signaling in brain.